Leptin Regulates Bone Formation via the Sympathetic Nervous System

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Leptin Regulates Bone Formation via the Sympathetic Nervous System

We previously showed that leptin inhibits bone formation by an undefined mechanism. Here, we show that hypothalamic leptin-dependent antiosteogenic and anorexigenic networks differ, and that the peripheral mediators of leptin antiosteogenic function appear to be neuronal. Neuropeptides mediating leptin anorexigenic function do not affect bone formation. Leptin deficiency results in low sympathe...

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ژورنال

عنوان ژورنال: Cell

سال: 2002

ISSN: 0092-8674

DOI: 10.1016/s0092-8674(02)01049-8